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02/04/2007 - The efficacy of frequency-specific acupuncture stimulation on extracellular dopamine concentration in striatum-A rat model study.

Country: Taiwan

Institute: Clinic of Acupuncture Therapy, Department of Pediatrics, Wanfang Medical Center, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, China Medical University, Taichung, Taiwan.

Author(s): Shen EY, Lai YJ.

Journal: 1: Neurosci Lett. 2007 Mar 26;415(2):179-84.


Acupuncture is a practice that has existed in Chinese society for thousands of years. Today, it is gaining greater acceptance and integration into medical practices of the western world. Its mechanism, however, remains elusive. Our study shows that only specific stimulation frequencies at specific acupoints will induce dopamine release in the corpus striatum, as demonstrated by in vivo microdialysis performed on Sprague-Dawley rats.

In the first trial, electroacupuncture (EA) stimulation at 15Hz and 15mA was conducted at six different points on the upper limbs of the experimental rats. These points mimic acupoints along six different meridians in the human body. Only Point 2 (corresponding to Pericardium 7) induced a response. In the second trial, EA stimulation at varying frequencies of 3, 6, 9, 12, 15, 18, 21, 24, 27 and 30Hz, and 15mA were conducted through Point 2. Stimulation at 6 and 15Hz induced an immediate response; 21Hz induced a response only after the ceasing of stimulation. All other frequencies failed to induce a response.

The data points to the importance of frequency-specific stimulation at specific acupoints for the release of neurotransmitters in the brain. We speculate that each meridian entails a stimulus of a specific frequency and intensity, which induces the release of its associated neurotransmitters or cytokines.

This is a concept with far-reaching clinical implications for acupuncture therapy, including the treatment of dopamine-related disorders.

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